Confirmed and Probable case
Criteria amended to include the reworked sections (laboratory definitive evidence; laboratory suggestive evidence; and clinical evidence) below.
The amended sections and criteria have been prepared to assist the classification of congenital syphilis involving a stillborn or neonatal death.
Laboratory Definitive Evidence
Relabelling “laboratory definitive evidence” to “laboratory definitive evidence (live birth)” and creation of “laboratory definitive evidence (stillborn)”.
Creation of “laboratory definitive evidence (stillborn)” to enable a stillborn, where serology was not possible, to be classified as a confirmed case in conjunction with “clinical evidence (confirmed)”.
Polymerase Chain Reaction (PCR) specified under nucleic acid amplification (NAA) test where this was not explicitly listed in previous case definitions.
Laboratory Suggestive Evidence
Relabelling “laboratory suggestive evidence” to “laboratory suggestive evidence (live birth) and creation of “laboratory suggestive evidence (stillborn)”.
Creation of “laboratory suggestive evidence (stillborn)” to enable cases involving a stillborn without serology but with laboratory evidence from the placenta, umbilical cord or amniotic fluid to be classified as a probable case.
Inclusion of Treponema pallidum-specific rapid immunochromatography to determine positivity in the mother of the congenital syphilis case.
Polymerase Chain Reaction (PCR) specified under nucleic acid amplification (NAA) test where this was not explicitly listed in previous case definitions.
Clinical Evidence
Restructuring of “clinical evidence” to “clinical evidence (confirmed)” and “clinical evidence (probable)”.
“Clinical evidence (confirmed)” enables expert pathology and clinical decision, in conjunction with “laboratory definitive evidence (stillbirth)”, to classify stillborn and neonatal deaths, where serology was not possible, as confirmed cases.
“Clinical evidence (probable)” is similar to “clinical evidence” in previous versions but now includes a non-exhaustive list of clinical evidence on physical examination and parameters to allow expert pathology and clinical decision to classify cases of congenital syphilis.
Notes
Notes added for stillbirth and livebirth, neonatal death, perinatal period and a minor update to treatment. |