The health and psychological consequences of cannabis use - chapter 5

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5. The accute effects of cannabis intoxication

5.3 Tolerance to acute effects

In animals, tolerance develops to the lethal, hypothermic and some of the behavioural effects of cannabinoids. This has been attributed to functional or pharmacodynamic adaptations of the CNS rather than to a more rapid metabolic disposition (Jaffe, 1985). Laboratory studies in humans involving daily dosing at high levels over periods of weeks have demonstrated tolerance to mood effects, tachycardia, decrease in skin temperature, increased body temperature, and impaired performance on psychomotor tests. Abrupt discontinuation in these studies usually produces a mild withdrawal syndrome (see below pp111-113).