Application Detail
Description of Medical Service
The proposed medical service is an IHC test for evaluation of PD-L1 expression to determine eligibility for treatment with atezolizumab in patients with locally advanced or metastatic TNBC who are previously untreated in the advanced setting. The biopsy sample taken as part of a standard diagnostic process will be used for immunohistochemical testing with PD-L1. The testing would be done by a pathologist alongside other immunohistochemical tests which are done routinely.Description of Medical Condition
Breast cancer is the most frequently diagnosed cancer among women and is the leading cause of cancer related deaths in women word-wide (1, 2). Triple negative breast cancer, a distinct subtype of breast cancer with the worst prognosis, is characterised immunohistologically by the lack of expression of hormonal estrogen receptor (ER) and progesterone receptor (PgR) and lack of overexpression and/or amplification of the human epidermal growth factor 2 (HER2)/NEU gene (3).Reason for Application
New MBS item(s)Medical Service Type
Co-dependent technologyPrevious Application Number
Not ApplicableAssociated Documentation
Application Form
Application Form (Word 118 KB)Application Form (PDF 789 KB)
Consultation Survey
Consultation Survey (Word 70 KB)Consultation Survey (PDF 394 KB)
PICO Confirmation
PICO Confirmation (Word 469 KB)PICO Confirmation (PDF 1315 KB)
Assessment Report
-Public Summary Document
Public Summary Document (Word 226 KB)Public Summary Document (PDF 742 KB)
Meetings for this Application
PASC
11 April 2019ESC
13-14 February 2020MSAC
3 April 202031 March - 1 April 2021