Application Detail
Description of Medical Service
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique used to test the presence or absence of specific chromosome regions and is often used to detect chromosome deletions such as 17p. This involves using a specific DNA probe which recognises the region to be tested. The probe is labelled with a fluorescent dye and is hybridised to the chromosomes on a microscope slide. It will only stick to its matched region. In a normal cell this will give two signals (one from each chromosome) and in a cell with a deletion will give only one signal.Description of Medical Condition
Chronic lymphocytic leukaemia (CLL) is a life-threatening B-cell malignancy which originates in the bone marrow and results in abnormally high numbers of white blood cells. CLL is an incurable disease with conventional therapies, with its natural history being one of repeated relapse. CLL patients harbouring a 17p deletion have a particularly poor prognosis and generally respond poorly to many of the chemotherapeutic agents used to treat CLL.Reason for Application
Amendment to existing MBS itemMedical Service Type
Co-dependent technologyPrevious Application Number/s
Not ApplicableAssociated Documentation
Application Form
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Consultation Survey
Consultation Survey (PDF 560 KB)Consultation Survey (Word 67 KB)
PICO Confirmation
-Assessment Report
-Public Summary Document
Public Summary Document (PDF 315 KB)Public Summary Document (Word 66 KB)