Application Detail
Description of Medical Service
The primary clinical purpose for monitoring minimal residual disease (MRD) is to determine the response to treatment and the risk of leukaemia relapse. Next Generation Sequencing (NGS) is a method which can be used to quantify and evaluate MRD. It involves the collection of genomic DNA from bone marrow aspirate or peripheral blood, which is then processed to identify the frequency and distribution of clonal sequences consistent with a malignant lymphoma and to quantify MRD over time in these patients.Description of Medical Condition
Acute lymphoblastic leukaemia (ALL) can occur at any age, but most cases arise in children younger than six years of age. Typical symptoms include fever, fatigue, bone or joint pain, bleeding, anorexia, abdominal pain, and hepatosplenomegaly. Despite most patients achieving a morphological remission, many will still have persistent MRD, which is the strongest predictor of relapse in ALL.Reason for Application
New MBS itemMedical Service Type
Investigative technologyPrevious Application Number/s
Not ApplicableAssociated Documentation
Application Form
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Consultation Survey
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PASC Consultation
PASC consultation closed
MSAC Consultation
MSAC consultation input closed Friday, 7 October 2022.
For further information please refer to PASC, ESC, MSAC Key Dates
For further information on the consultation process please refer to MSAC Consultation Process
PICO Confirmation
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Assessment Report
-Public Summary Document
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