Application Detail
Description of Medical Service
Radionuclide scintigraphy with 99mTc-labeled pyrophosphate (PYP), 99mTC-labeled oxidronate (HDP) or 99mTc-labeled 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) is sensitive and specific for imaging cardiac ATTR amyloid and enables a diagnosis of ATTR-CM. A standard protocol includes whole-body scans after injection. Heart and whole-body retention and heart to whole-body retention ratio can be semi-quantitatively analysed from early whole-body counts.Description of Medical Condition
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease characterised by accumulation of amyloid fibrils composed of misfolded transthyretin protein in the heart. Misfolded monomers or oligomers of transthyretin are deposited in the myocardium, leading to cardiomyopathy and symptoms of heart failure.ATTR-CM is a late-onset disease occurring predominately in male patients aged 60 years or older. ATTR-CM can be inherited as an autosomal dominant trait caused by pathogenic mutations in the transthyretin gene TTR (ATTRm) or by deposition of wild-type transthyretin protein (ATTRwt), previously called senile systemic amyloidosis.
Reason for Application
New MBS itemMedical Service Type
TherapeuticPrevious Application Number/s
Not applicableAssociated Documentation
Application Form
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Consultation Survey
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