Application Detail
Description of Medical Service
The proposed medical service is testing of prostate tumour tissue to detect BRCA1/2 (BReast CAncer gene) gene variants in men with metastatic castration-resistant prostate cancer to determine eligibility for treatment with olaparib.Description of Medical Condition
When localised, prostate cancer can be cured with surgery or radiotherapy, but some patients will relapse with either overt metastases or an isolated rise in prostate-specific antigen. There is also a proportion of men who have metastases when the prostate cancer is first diagnosed. Prostate cancer is termed ‘castrate resistant’ when the disease progresses despite continuous androgen deprivation therapy. After this, further treatment is needed to maintain disease control.This application concerns the metastatic disease, which is a small part of the overall disease and is furthermore targeted at those patients with genetic mutations in their homologous recombination repair (HRR) genes. A small percentage of prostate tumours have loss of function mutations in candidate genes involved in HRR of DNA. BRCA1, BRCA2, or ATM are the most well characterised and/or frequently mutated HRR genes in prostate cancer. The overall mutation frequency for these three genes together range from 13% to 26.5% in metastatic castration resistant prostate cancer
Reason for Application
New MBS itemMedical Service Type
InvestigativePrevious Application Number/s
Not ApplicableAssociated Documentation
Application Form
Application Form (PDF 1381 KB)Application Form (Word 280 KB)
Consultation Survey
Consultation Survey (PDF 561 KB)Consultation Survey (Word 68 KB)
PICO Confirmation
PICO Confirmation (PDF 1552 KB)PICO Confirmation (Word 1194 KB)
Assessment Report
-Public Summary Document
Public Summary Document - March-April 2021 (PDF 1026 KB)Public Summary Document - March-April 2021 (Word 1651 KB)
Public Summary Document - November 2021 (PDF 1928 KB)
Public Summary Document - November 2021 (Word 2614 KB)
Meetings for this Application
PASC
17 April 2020ESC
11-12 February 2021MSAC
31 March - 1 April 202125-26 November 2021