Pathology results are one of the major tools used by health professionals to measure the status and progress of thrombotic diseases. Health professionals use pathology results to communicate information about chronic diseases, including severity, current status and historical data (van der Kam et al. 1998). Given the importance of pathology results in on-going management of chronic disease, it is somewhat surprising that only a handful of studies have looked at improving the readability of pathology reports. Some recent studies have proposed using standardized formats to improve readability for clinicians (Dandurand et al. 2006; Pantanowitz et al. 2007). However, improving the patient’s comprehension of health problems actually requires a more fundamental redesign based on patient information needs (Gould 2004). Some exploratory work has looked at the use of patient-oriented web sites (Clayman et al. 2008), and at the effectiveness of cartoons to explain wound care to patients after discharge (Delp and Jones 1996). Unfortunately, those studies are not based on any systematic theory of consumer information needs and so provide little guidance about how to structure reports to either improve patient comprehension of the condition or motivate the patient to manage that condition actively.